I find this letter from John Carmack interesting in that it summarizes a sentiment I've heard from literally all of the highest impact/most effective people I've talked to at large companies:
You can make a big difference, but you're constantly fighting against a self-sabotaging organization.
I know some fairly high impact people who aren't bothered by this kind of thing; those people tend to say things like "I try not to care too much" or "I used to get too frustrated, so now I [do less].
Of course there are also people who say that this kind of thing isn't a problem for various reasons, but people who say that tend to not be very effective.
Perhaps this is just the nature of large orgs, but it seems quite unfortunate that the orgs with the most resources are constantly sabotaging themselves and that the most effective people spend a large fraction of their time fighting extremely obvious problems that don't really seem like they should exist in the first place.