in fact, this is possibly the case with a lot of chromosomal abnormalities aside from the sex chromosomes, but the sex chromosomes already have random X-inactivation programmed within them. As long as you have at least one X, you're fine

(no X's and you're dead because the genes on the X chromosome are, interestingly, unrelated to genitals or sex differentiation. those are scattered elsewhere in the genome. lol)