4/ London would became a great port - but there was a problem: navigation remained challenging - specifically determining longitude.
In 1675 the Royal Observatory was established in Greenwich, East London "so as to find out the so much desired longitude of places for the perfecting of the art of navigation".
The Longitude Act of 1714 created a huge financial reward for anyone who could solve it https://en.wikipedia.org/wiki/Longitude_Act
We can highly recommend Sobel's "Longtitude" to learn more.
5/ In 1854 an outbreak of cholera hit Soho in central London, killing hundreds.
Dr. John Snow, a believer in the theory that unseeable, waterborne "germs" caused the disease, plotted the cases on map to find the infected water pump that was responsible for the outbreak.
https://en.wikipedia.org/wiki/1854_Broad_Street_cholera_outbreak
Today Snow is heralded as a father of the field of epidemiology. A pub named after him is located at the site.