@Gargron It's the base i used for my site. I think the biggest downside I've noticed is that it works very well unless you want to do more advanced stuff.
IE, I had to write my own rules for smallcaps and lists with other item-types than disc or numerical.
@Gargron If you like Tailwind you're going to love UnoCSS (https://uno.antfu.me/play/) It basically gives you Tailwind but without the overhead and extremely fast.
(meant in jest, but after years of devs laughing at those of us who use modular PHP CMSs because they're easy, quick (and save many of us learning to code)… I am enjoying how Tailwind has replaced Bootstrap as non-CSS-design-devs go-to tool, as, even though it's verbose & bloatey like Bootstrap, it's easier to make things look nice/as you want).