The Intel 386 processor (1985) was a key step in the evolution of x86, moving to 32 bits as well as a CMOS implementation. A less visible design change is its use of standard cell logic (marked in red), building many circuits from standardized building blocks. 1/17
The 386 was originally scheduled for 50 person-years of development time, but it fell behind schedule. The designers made a risky decision to use "automatic place and route", letting software do some layout. This worked and the chip was completed ahead of schedule. 2/17