“Marra’s October 2023 meta-analysis found that two [vaccine] doses reduced long COVID likelihood by 36.9 percent and three doses reduced it by 68.7 percent. And in a study published last year in the Journal of the American Medical Association, other researchers found that the prevalence of long COVID in health care workers dropped from 41.8 percent in unvaccinated participants to 30 percent in those with a single dose, 17.4 percent with two doses and 16 percent with three doses.”
https://www.scientificamerican.com/article/vaccination-dramatically-lowers-long-covid-risk/
I filed “multiple vaccine doses provide substantial defense against long COVID” under “big if true” when studies indicating that emerged last year, but now that there are multiple independent confirmations it seems safe to move it to the “just plain big” file