Finally moved my work machine to #guix system! It went surprisingly well as most of my set-up is free software anyways.
I had a requirement to be able to run docker (ugh) for maintaining compatiility to company-wide workflows as well as a debian VM out of the same reason (as we usually deploy to debian servers), and to be able to use nix to keep compatibility to my previous set-up.
Others than that I use gpg-agent as my ssh-agent instead of opensshs stock one, emacs as my computing/development environment, and a bunch of tooling for different programming languages.
It's quite nice to see that my favorite OS is a good fit for my work along the lines of software development, debugging and system administration as well!