@Andres Yes, Aral famously is one such big user able to melt other people's instances. ;) https://ar.al/2022/11/09/is-the-fediverse-about-to-get-fryed-or-why-every-toot-is-also-a-potential-denial-of-service-attack/
However I think the far worse problem is that by default Mastodon doesn't control at all whether ActivityPub requests are coming from a "real" ActivityPub server/user, so I believe it's still easy to produce a spam wave like https://github.com/mastodon/mastodon/issues/21977 .
@nemobis
Thanks for the link to Aral's article!
Yes I have been thinking about exactly that an how a potential millions-of-followers user back in Threads would kill any instance.