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mhoye

jfc this paper

"Profound similarities between highly nAChR affine toxins (i.e., from snakes of the Ophiophagus (cobra) [...], Rabies lyssavirus [...] strains [...] and Cobratoxin (naja siamensis) [...] and SARS-CoV-2 specific proteins were found by analyzing the toxin’s amino-acid (aa) sequence alignment and comparing it to the motifs in spike glycoprotein (SGP) from SARS-CoV-2."

bioelecmed.biomedcentral.com/a

Our group recently described the crucial relevance of autonomic balance for the severity of COVID-19 disease courses (Leitzke et al. 2020; Leitzke and Schönknecht 2021) and highlighted the significance of nicotinic acetylcholine receptors (nAChRs) for the limiting regulation of cytokine liberation and virus replication on the transcriptional level, restricting NF-KB action along the cholinergic anti-inflammatory pathway (CAP) (Leitzke et al. 2020; Leitzke and Schönknecht 2021). Profound similarities between highly nAChR affine toxins (i.e., from snakes of the Ophiophagus (cobra) and Bungarus genera, the G-ectodomains of three Rabies lyssavirus (formerly Rabies virus) (RABV) strains (Changeux et al. 2020) or muscarinic toxin-like protein and Cobratoxin (naja siamensis) (Farsalinos et al. 2020)) and SARS-CoV-2 specific proteins (Farsalinos et al. 2020; Changeux et al. 2020) were found by analyzing the toxin’s amino-acid (aa) sequence alignment and comparing it to the motifs in spike glycoprotein (SGP) from SARS-CoV-2 (Farsalinos et al. 2020; Changeux et al. 2020).
22 November at 17:57 | Open on mastodon.social
1 comment
mhoye

Paraphrased, that reads "At a molecular level, parts of the Covid19 virus look and seemingly behave a lot like cobra venom and rabies."

Turns out being "covid cautious" is just a revealed preference for not wanting strangers to sneeze rabies and snake venom analogues into your lungs.

Wear a mask.

22 November at 18:04 | Open on mastodon.social
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